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ANOVA: Analysis of Variance

ANOVA, or analysis of variance, is a statistical procedure you will often see mentioned and used in scientific literature. But what is it? Arun Kumar offers a nice look at this technique in a blog post from 2013 (http://blog.minitab.com/blog/statistics-in-the-field/understanding-anova-by-looking-at-your-household-budget). He begins by noting that in order to understand ANOVA, you need to grapple with...
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Ethics in Clinical Research

In reading clinical research, one thing a practitioner may not think to consider is the human subject ethics of the project they are reviewing. Yet this is an important part of the research, and it is supposed to be reported. What you would look for would be a statement that the participants in the...
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Outcome Switching in Scientific Publication

Much of my career has been spent working in part as a journal editor, as a scientist and researcher, and as a teacher. In my current teaching position, I teach a course on evidence-based chiropractic practice. Part of that course is given over to critical appraisal of literature. The reason for placing emphasis on...
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And Even More on Diagnostic Testing

Our last two blog posts, by myself and my colleague John Stites, have dealt with issues related to diagnostic testing. I discussed the importance of cut-off points and how changing them affects the sensitivity and specificity of a test. John discussed the concept of SPin and SNout and related cautions in interpreting them. Let...
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The Importance of a Cut-Off Point

In the last column, my colleague Dr. John Stites provided additional insight into the concept of SpIN and SnOut, which are related to the larger concept of sensitivity and specificity. To remind you, sensitivity is the percentage of people who have the disorder in question and whom test positive on a given diagnostic test....
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At the Speed of Light

I am reading a book which, on its surface, may seem to have little to do with evidence-based practice. The book is “Virtual Unreality,” by Charles Seife. It is about how the internet allows us to spread information faster than we have ever seen before, while reaching more people in more rapid a time...
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Some Thoughts on Evidence-Based Practice and Decision Making

Dr. Tricia Greenhlagh has been someone who has immensely influenced my thinking. She is a professor of primary care health sciences at the University of Oxford, and she wrote a great little book called “How to Read a Paper: The Basics of Evidence-Based Medicine.” (1) She now also adds a blog to her list...
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The Evidence Hierarchy Evolving

By now, we have all been exposed to the evidence pyramid. This is a graphic that demonstrates the apparen6t hierarchy of scientific papers, with those with the least rigor located at the bottom of the pyramid, and those with the most at the top. So, we have anecdote and case reports located near bottom,...
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Seminal Papers in Evidence-Based Medicine

There are simply thousands of papers on evidence-based practice, but sometimes it is good to see how it all started. Below are some of the seminal papers on EBM that were published in the early days of the movement. Evidence-Based Medicine Working Group. Evidence-based medicine. A new approach to teaching the practice of medicine....
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Apps for Evidence-Based Practice

We live in a busy and mobile world where we have access to more information on our cell phones that earlier people did by visiting a library. And we live in a world where evidence is increasingly important to us in the practice of chiropractic. Can we yoke our developing technology to our practices?...
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